Combining 1,3-ditriazolyl-benzene and quinoline to discover a new G-quadruplex interactive small molecule active against cancer stem-like cells. Mendes E, Cadoni E, Carneiro F, Afonso MB, Brito H, Lavrado J, Dos Santos DJVA, Vítor JB, Neidle S, Rodrigues CMP, Paulo A. Polymorphic G:G mismatches act as hotspots for inducing right-handed Z DNA by DNA intercalation. Substituted Naphthalenediimide Compounds Bind Selectively to Two Human Quadruplex Structures with Parallel Topology. Vo T, Oxenford S, Angell R, Marchetti C, Ohnmacht SA, Wilson WD, Neidle S. A G-quadruplex-binding compound shows potent activity in human gemcitabine-resistant pancreatic cancer cells. PMID 32832034 DOI: 10.1021/Acsmedchemlett.0C00317Īhmed AA, Marchetti C, Ohnmacht SA, Neidle S. Asymmetrically Substituted Quadruplex-Binding Naphthalene Diimide Showing Potent Activity in Pancreatic Cancer Models. PMID 33227941 DOI: 10.3390/molecules25225407Īhmed AA, Angell R, Oxenford S, Worthington J, Williams N, Barton N, Fowler TG, O'Flynn DE, Sunose M, McConville M, Vo T, Wilson WD, Karim SA, Morton JP, Neidle S. A G-Quadruplex-Binding Small Molecule and the HDAC Inhibitor SAHA (Vorinostat) Act Synergistically in Gemcitabine-Sensitive and Resistant Pancreatic Cancer Cells.
Beyond the double helix: DNA structural diversity and the PDB. Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction. Jhan CR, Satange R, Wang SC, Zeng JY, Horng YC, Jin P, Neidle S, Hou MH. Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids. Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism. Satange R, Kao SH, Chien CM, Chou SH, Lin CC, Neidle S, Hou MH.
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